3D adipose tissue bioprinting method could enhance skin regeneration – Medical Xpress
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To overcome this limitation, a research team led by Assistant Professor Byoung Soo Kim from the Pusan National University, Korea, has developed a novel adipose tissue biofabrication approach. This paper was made available online on February 2, 2025 in Advanced Functional Materials. The highlight of this study was the development of a hybrid bioink, which is a combination of 1% adipose-derived decellularized extracellular matrix and 0.5% alginate. This hybrid bioink limited the migration of preadipocytes, the fat cell precursors, while promoting their differentiation.
Dr. Kim states, “Under standard culture conditions, preadipocytes tend to proliferate and migrate, preventing the formation of lipid droplets that are essential for adipose tissue functions. The hybrid bioink developed in this study maintains the physiological properties of the adipose tissue.”
Additionally, a diameter of ≤ 600 µm was deemed to ensure sufficient nutrient and oxygen delivery for the fabricated adipose tissue. Furthermore, bioprinted adipose tissues arranged with a spacing of ≤ 1000 µm promoted adipogenesis via paracrine signaling. The optimized 3D bioprinted adipose tissues rapidly promoted the migration of skin cells in vitro by modulating the expression levels of cell migration-related proteins (MMP2, COL1A1, KRT5, and ITGB1).
